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International Journal of Cancer Frontiers. 2020; 1: (1) 1; DOI: 10.12208/j.ijcf.20200001.

The Current Progress of Sirtuins Family Maintain Genomic Stability
Sirtuins家族维持基因组稳定性的研究进展

作者: 陈思齐,胡烨,谢妮*

广州医科大学

深圳市第二人民医院生物样本库

*通讯作者:谢妮,单位:深圳市第二人民医院生物样本库;

引用本文: 陈思齐,胡烨,谢妮. Sirtuins家族维持基因组稳定性的研究进展[J]. 国际肿瘤前沿杂志, 2020, 1(1) : 1-5.
Published: 2020-06-18

摘要

人烟酰胺腺嘌呤二核苷酸(DAN+)依赖的脱乙酰基酶Sirtuins家族,广泛参与了细胞代谢、细胞周期及维持基因组稳态的调控。Sirtuins家族成员通过不同方式参与了对基因组稳态的调控,如:防止DNA损伤并促进DNA修复、组蛋白和非组蛋白靶标的脱乙酰基化等。近年来随着研究的深入,对Sirtuins家族在基因组稳定性调节中的作用有了更深的理解,本文着重对Sirtuins家族在维持基因组稳态调节的最近进展进行回顾和总结。

关键词: Sirtuins;基因组稳定性;DNA损伤;DNA修复

Abstract

Human Sirtuins family is an nicotinamide adenine dinucleotide(NAD+)-dependent protein deacetylases, which deeply involved in regulation of cellular metabolism, cell cycle progression and maintenance of genomic stability. Members of Sirtuins are involved in the regulation of genomic homeostasis through different pathways, such as prevent DNA damage and promote DNA damage repair, deacetylate both histone and non-histone targets. With further research, the role of sirtuins family in the regulation of genome stability has been further understood. This paper reviews and summarizes the recent progress of sirtuins family in the regulation of genome stability.

Key words: Sirtuins; Genomic Stability; DNA Damage; DNA Repair

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